What We Offer

At AccuraScience, we provide expert, customized bioinformatics services aligned with your research questions, data types, and downstream goals. Our clients span academia, biotech, and pharma — from exploratory studies to regulated clinical programs.

Founded in 2013, AccuraScience was the first U.S.-based bioinformatics service company offering broad-spectrum customized solutions to academic and industry researchers.

Our team of senior bioinformaticians brings over 200 years of combined experience, with deep biological insight and computational rigor.

We’ve successfully completed projects for 180+ research institutions, contributed to NIH-funded grants, and supported numerous peer-reviewed publications and clinical applications.

🔬 Short-Read Sequencing & Core Omics Analysis

• - Whole-genome and exome data — genome assembly, precise variant calling, copy number detection
• - Targeted panels & amplicons — high-confidence variant calls, depth/coverage QC, low-frequency detection
• - RNA-seq — expression quantification, differential testing, splicing analysis, de novo assembly, variant-aware quantification
• - Epigenomics — ATAC-seq, ChIP-seq, CUT&Tag, CUT&RUN, Hi-C (our expert’s guide on ATAC-seq & CUT&Tag)
• - DNA methylation — WGBS, RRBS, EPIC array, scBS-seq (common pitfalls blog)
• - Single-cell — scRNA-seq, scATAC-seq, Multiome (how to analyze sc epigenomics correctly; Multiome profiling pitfalls)
• - Spatial transcriptomics — Visium, Xenium, CosMx (our expert's spatial analysis guide)

🧬 Long-Read Sequencing & Hybrid Genome Analysis

• - Genome assembly & structural variant detection — tuned Flye/Canu pipelines, multi-round polishing (long-read genome assembly blog)
• - Full-length RNA isoform analysis — Iso-Seq, direct RNA, chimera removal, clustering, comparison to RefSeq
• - Base modification detection — long-read methylation, cross-platform validation
• - Hybrid assemblies — optimized integration of short- and long-read data (hybrid integration blog)

🔗 Multi-Omics Integration & Cross-Layer Analysis

• - Integrated analysis of RNA-seq, ATAC-seq, methylation, proteomics, metabolomics (multi-omics analysis blog)

🧪 GWAS, EWAS, TWAS, and Population-Level Analysis

• - Full pipeline support — from raw data through final association tables and figures
• - Confounder correction — population structure, rare variants, LD inflation, summary stat interpretation (GWAS essentials blog; GWAS pitfalls blog; Beyond GWAS blog)

🤖 AI, Machine Learning & Structural Modeling

• - Cancer subtyping, biomarker discovery, image-based diagnostics (e.g., CNN on pathology slides)
• - Drug response modeling and multi-omics prediction
• - AlphaFold 2 & 4 — structure prediction, interface modeling, domain annotation (AlphaFold 2 blog; AlphaFold 4 blog)
• - LLMs in biology — applications of transformer and foundation models in omics (10 real-world AI use cases; practical AI modeling tips)

🦠 Microbiome & Metagenomics

• - 16S and shotgun metagenomics — taxonomic profiling, functional annotation, alpha/beta diversity, host-microbe associations (microbiome analysis guide)

🧫 Proteomics & Mass Spectrometry

• - Quantitative proteomics — DIA, TMT pipelines, differential abundance
• - Robust pre-processing — imputation, normalization, batch effect removal (solving proteomics analysis challenges)

🛠️ Custom Pipelines & Troubleshooting

• - Assay-specific quirks — noisy peaks, over-tagmentation, fragment bias, dropout
• - Pipeline issues — alignment, feature counting, methylation caller conflicts (peak and methylation troubleshooting blogs, DNA methylation pitfalls)

📌 Resources & Next Steps

• ➡️ - Meet Our Team — 200+ years of expertise across academia, biotech, and clinical domains
• ➡️ - 10 Reasons to Work With Us — including cost-effectiveness, rigor, and grant/publication support
• ➡️ - Testimonials — direct feedback from clients who’ve published or secured funding
• ➡️ - How It Works — simple, transparent project process
• ➡️ - Pricing — clear deliverables and fair costs
• ➡️ - FAQs — turnaround, file types, what’s included
• ➡️ - Our Blogs — expert insights, technical guides, and analysis pitfalls to avoid
• ➡️ - Send an Inquiry or Chat With Us — let’s discuss your needs today